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Florentina Negoita

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Open access Aug 2026

Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors

Abstract The mammalian/mechanistic Target of Rapamycin Complex 1 (mTORC1) orchestrates cell growth and metabolism in response to diverse extracellular and intracellular cues. mTORC1 phosphorylates a broad range of substrates, each of which plays important physiological roles. Emerging evidence suggests that mTORC1 can...

Samuel J. Atkinson, Florentina Negoita, Yuichiro Ioi et al. · 0 citations

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