Author

Florian Hugi

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Open access Aug 2026

Reliable single-cell perturbations explain and improve model performance

This work tests the reliability of perturbations and their alignment with shared perturbation responses, classifying each perturbation as specific, shared, or unreliable, and applies these quality labels to published benchmarks shows that model comparisons depend on perturbation quality.

Xi Wang, J. Kuipers, Florian Hugi et al. · bioRxiv · 0 citations

Open access Aug 2026

An end-to-end computational framework for “Record-seq” transcriptional recording data

To address the primary computational bottleneck of spacer sequence extraction, a wavefront alignment approach is implemented for efficient quasi-local pattern matching, achieving an approximately 30-fold speedup and introducing transcription unit-based feature counting as an alternative to gene-body quantification to b...

Florian Hugi, Tanmay Tanna, Randall J. Platt · Bioinformatics · 0 citations