Aug 2026
LncRNA-mediated organization of oncogenic chromatin state is a targetable vulnerability in leukemia
This study uncovers a therapeutic vulnerable lncRNA-centric circuitry and provides compelling preclinical evidence for the development and application of a novel RNA targeting-LNP based therapy for treatment of myeloid leukemia.
Zhenggen Jin, Brendan D. Ma, Karen Y. T. Chan et al.
· bioRxiv · 0 citations