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Author

Fran Supek

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Open access Sep 2026

Single genome analysis of normal cells identifies the early steps of kidney cancer

Whole genome analyses have shown that every cell of the body accumulates thousands of genetic changes during a lifetime, with implications for cancer initiation. We have analyzed normal kidney cells from both healthy individuals and patients with the Von Hippel Lindau (VHL) syndrome, which predisposes to kidney cancer....

J. P. Margaria, G. Pipitone, A. Larcher et al. · 0 citations
Open access Jul 2026

The genetic architecture of human programmed stop codon readthrough

This study provides comprehensive quantitative maps of the sequence determinants of human programmed readthrough and suggests that three examples of programmed readthrough are located on distinct local fitness peaks, each defined by different upstream and downstream architectures built around a shared CUAG core motif.

Ignasi Toledano, Fran Supek, Ben Lehner · 0 citations

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