Pyridobenzothiazolones as non-nucleoside antivirals: From HCV polymerase inhibition to broad-spectrum antiviral agents.
Pyridobenzothiazolones (PBTZs) are tricyclic compounds originally investigated as chemotypes directed against viral RNA-dependent RNA polymerases. Following the first reports on hepatitis C virus (HCV) NS5B inhibition, medicinal chemistry optimization and mechanistic studies have expanded the antiviral profile of this...