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Author

Francesco Benedetti

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Open access Aug 2026

A Delphi-method-based consensus for clinical domains and assessment of the inflammatory subtype of major depressive disorder from the ASPIRE study.

BACKGROUND Elevated inflammatory biomarkers have been consistently associated with a subset of depressive symptoms, particularly atypical and energy-related features, as well as antidepressant treatment resistance. This evidence has supported the definition of an inflammatory subtype of major depressive disorder (ISMDD...

B. Vai, T. Cazzella, C. Monopoli et al. · 1 citation
Aug 2026

History of childhood trauma enhances the detrimental effects of recent stressors on brain structure and function in major depressive disorder.

Childhood trauma moderated the association between recent stress exposure and structural and functional brain measures in MDD, particularly within prefrontal regulatory regions, consistent with stress sensitization models and suggest that early adversity may contribute to heterogeneity in neural correlates of stress in...

S. Furno, Marco Paolini, C. Milano et al. · 0 citations

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