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Francisco Bezanilla

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Open access Sep 2026

Mechanistical and structural basis of Kv channel inhibition by 4-aminopyridine

Inhibition of Kv channels by 4-aminopyridine (4AP) improves motor function in multiple sclerosis by enhancing neuronal excitability. The mechanism of inhibition and the structural basis of 4AP binding to Kv channels remain unclear. Here, we determined the structure of the Shaker V369I-I372L-S376T (ILT) mutant bound to...

Bernardo I. Pinto-Anwandter, Richa Agrawal, Trayder Thomas et al. · 0 citations

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