Author

Francisco Mura

3 papers indexed here

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Open access Oct 2026

Design and synthesis of hydrolyzable coumarin–naphthalimide dual probes for NIR fluorescence detection and selective photodynamic activity in cancer cells

Developing multifunctional agents capable of combining diagnostic and therapeutic functions remains a major challenge in cancer research. Herein, we report the design, synthesis, and photophysical characterization of a family of dual probes (C-NAF) based on coumarin–naphthalimide hybrids linked through an imine bond, c...

Benjamín Zúñiga-Salazar, Paula S. Rivero-Jerez, Sofía Pérez-Del Pino et al. · RSC Advances · 0 citations

Open access Sep 2026

Tryptophan substitutions reveal cooperative membrane transitions and aromatic interactions associated with membrane permeabilisation in CM15 and MSI-78 peptide analogues.

Antimicrobial peptides CM15 (Ac-KWKLFKKIGAVLKVL-NH2) and MSI-78(11-22)-NH₂ (Ac-CKFGKAFVKILKK-NH2) have remarkable abilities to interact with negatively charged lipid bilayers, adopting helical secondary structures while embedded within the membrane, and, with increasing peptide concentration, evolving toward aggregatio...

Matías Zapata-Lizama, Y. Vásquez-Martínez, Patricio Briones-Rebolledo et al. · Bioorganic chemistry (Print) · 0 citations

Sep 2026

Molecular Basis of Dual-Site Engagement and Selectivity of CcoTx3-synth for hNaV1.5.

These findings provide the first structural and functional insights into the selective multisite engagement of CcoTx3-synth with hNaV1.5 and may guide the design of peptide therapeutics targeting cardiac channelopathies.

Erbio Díaz-Pico, Luciano Peña-Tejo, Pablo Barrías et al. · European Journal of Pharmaco... · 0 citations