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Author

Frank Furnari

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Open access Sep 2026

SNP rs2853669 potentially elevates the risk of glioblastoma development and leads to worse prognosis when in cis with mutant TERT promoter in a Japanese cohort.

BACKGROUND Mutations in the telomerase reverse transcriptase (TERT) promoter region (TPM), particularly C228T and C250T, are common in IDH-wildtype glioblastoma (GBM). The single nucleotide polymorphism (SNP) rs2853669, also located in the TERT promoter, may influence telomerase activity, though its clinical relevance...

Daisuke Kawauchi, Yohei Miyake, B. Taylor et al. · 0 citations
Jul 2026

Reprogramming of Glioblastoma-Immune Crosstalk to Overcome Immunotherapy Failure 2258791

Glioblastoma multiforme (GBM) is a lethal brain cancer with a median survival of less than a year. Immunotherapies, such as immune checkpoint blockade (ICB), represent promising treatment options but still face challenges due to tumor resilience. Understanding how the brain and tumor environment shape immune resp...

Shuozhi Liu, Lizmarie Garcia-Rivera, Michael A. LaPorta et al. · 0 citations

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