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Author

Frank M. Longo

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Open access Oct 2026

A Small-Molecule TrkB Agonist Promotes Synaptic Resilience Against Aβ and Tau Oligomers and Mitigates Alterations in TrkB-Akt and Fyn Signaling

Highlights What are the main findings? In vitro, PTX-BD4-3 protected against oAβ-induced synaptic protein loss and elevation of Fyn, NR2B, and tau phosphorylation. Preservation of synaptic proteins following oAβ exposure was TrkB-dependent. PTX-BD4-3 also protected against oTau-induced dendritic spine loss. In APPL/S m...

Tao Yang, Kevin C. Tran, Albert Leng et al. · 0 citations

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