Frazer J. T. Buchanan

The proteasome and ERAD pathways can regulate hepatitis E virus pORF1 proteostasis and genome replication

Hepatitis E virus (HEV) is a major cause of acute viral hepatitis, with an estimated 20 million human infections annually. Its diverse host range presents a significant zoonotic threat, yet the molecular mechanisms underpinning HEV–host interactions remain poorly characterised. Here, we used transposon-based insertion...