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Author

Frédérick A. Mallette

2 papers indexed here

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Open access Sep 2026

eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma

Findings show that multiple resistance-associated programs spanning signaling, cell survival, and metabolism share a dependency on eIF4A-dependent translation and provide a preclinical rationale to test whether adding eIF4A inhibition can prolong responses to MAPK-targeted therapy in melanoma.

Alejandro Schcolnik-Cabrera, Meriem Takdenti, Anavasadat Sadr Hashemi Nejad et al. · 0 citations
Open access Aug 2026

SMOC2 promotes partial epithelial-mesenchymal transition and maladaptive repair in renal tubular epithelial cells

It is shown that SMOC2 localized to the basement membrane of injured TECs across 3 murine models of kidney injury and induced a partial epithelial-to-mesenchymal (EMT) transition in TECs, and its extracellular calcium-binding domain mediated binding to the decellularized extracellular matrix accounted for most of its e...

Schrodinger Cenatus, Peng Gao, Nathalie Henley et al. · 0 citations

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