Author

Fu-Jie Diao

2 papers indexed here

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Oct 2026

A tunable brain-targeted PEGylated ginsenoside Rg1 derivative disrupts the ROS-mediated inflammasome-pyroptosis cascade to ameliorate Alzheimer's cognitive deficits.

The pathogenic cascade of oxidative stress, neuroinflammation, and pyroptosis serves as a core driving factor in the pathogenesis and progression of Alzheimer's disease (AD). Although ginsenoside Rg1 exhibits pleiotropic neuroprotective activities, its poor blood-brain barrier (BBB) permeability severely hinders its cl...

Xing Zhu, Hao-Yu Liang, Lei Fan et al. · Biomaterials · 0 citations

Sep 2026

Nrf2 overexpression ameliorates cognitive deficits and neuronal damage in APP/PS1 mice via attenuation of Aβ deposition and neuronal ferroptosis.

Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) deposition, yet the mechanisms underlying Aβ-induced neuronal damage remain elusive. Emerging evidence implicates ferroptosis, an iron-dependent form of regulated cell death, in AD pathology. We hypothesized that dysfunction of the Nrf2 pathway critically l...

Xing Zhu, Jin-Yao Bo, Yu-Lu Qian et al. · Neuroscience Letters · 0 citations