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Fu-Jie Xie

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Open access Sep 2026

Recombinant Toxoplasma gondii expressing OVA confers antigen-specific protection against Eimeria falciformis

Coccidiosis, caused by protozoan parasites of the genus Eimeria, remains a major enteric disease that requires effective antigen-specific cellular immunity for protection. In this study, we evaluated genetically engineered Toxoplasma gondii, an apicomplexan parasite closely related to Eimeria, as a live-vector platform...

Ying-Ying Sun, Yi-Lin Yang, Fu-Jie Xie et al. · 0 citations
Aug 2026

Recombinant Toxoplasma gondii expressing FIPV spike protein S1 subunit: A proof-of-concept approach against toxoplasmosis and feline infectious peritonitis.

Feline infectious peritonitis virus (FIPV) is a lethal feline pathogen with no widely effective prophylactic vaccine available. To address this unmet need, we explored the feasibility of using Toxoplasma gondii (whose definitive host is felids) as a live delivery platform to develop a bivalent vector vaccine. We genera...

Fu-Jie Xie, Xin-Yun Jiang, Yi-Lin Yang et al. · 0 citations

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