Fu-Quan Du

The osteoarthritis inflammatory ecosystem: a node-edge-boundary-emergent framework toward precision stratification and therapeutic hypothesis generation

Osteoarthritis (OA) is a heterogeneous whole-joint disorder in which pain, structural progression and treatment response often diverge from radiographic severity. This mismatch has limited disease-modifying OA drug development and highlights the need for biologically informed patient stratification. Chronic low-grade i...