Background Pain following traumatic brain injury (TBI) is a major challenge in clinical management. Neuroinflammatory responses, particularly those involving microglia, are increasingly implicated in the synaptic and circuit‐level remodeling associated with post‐TBI pain. However, the conventional M1/M2 framework does...
Fu Zhao, Jing-Ru Shi, Yi-Min Zhang et al.· Pain Research and Management· 0 citations
BACKGROUND
Traumatic brain injury (TBI) remains a leading cause of mortality and long-term neurological disability worldwide. The cellular heterogeneity and intercellular communication in the injured brain remain incompletely defined, particularly the astrocyte-neuron crosstalk that could drive potential interventions....
Fu Zhao, Lu-Xi Cao, Jia-Nan Chen et al.· Brain Research· 0 citations
Systemic inflammatory response syndrome (SIRS) carries high ICU morbidity, sepsis lacks standardized therapies, and stage-variable natural killer (NK) cell function in SIRS remains poorly defined due to insufficient single-cell evidence. Herein, we analyzed public LPS-induced SIRS peripheral blood single-cell RNA seq...
Hong-Ling Jia, Hang Zhao, Yan Li et al.· Clinical and Experimental Me...· 0 citations
Melanoma remains challenging due to pronounced heterogeneity, early metastasis, and dynamic treatment resistance. Conventional tissue biopsy and imaging provide essential information but are limited by invasiveness, sampling bias, and an inability to capture longitudinal tumor-immune evolution. As endogenous bio-nanoma...
Li Li, Xin Zheng, Jingrui Shi et al.· Microstructures· 0 citations
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