Transformed small-cell lung cancer (T-SCLC) is a clinically important form of histologic transformation and a mechanism of acquired resistance in non-small-cell lung cancer (NSCLC). It is associated with poor prognosis, with a median overall survival of only about 9–13 months. This review summarizes recent advances in the mechanisms, diagnosis, monitoring, and treatment of T-SCLC. Repeat biopsy remains the gold standard for confirming histologic transformation, whereas molecular profiling and liquid biopsy may facilitate early detection and longitudinal disease monitoring. Platinum-etoposide remains the most commonly used clinical standard after transformation, but its benefit is typically transient and durable disease control remains uncommon. Continuation of
EGFR
tyrosine kinase inhibitors combined with chemotherapy may prolong progression-free survival in selected patients but has not consistently improved overall survival. Anti-angiogenic therapy, particularly anlotinib, and chemo-immunotherapy have shown encouraging activity in selected patients, while emerging strategies targeting
DLL3
,
MYC
,
SOX2
, and epigenetic regulators may broaden the therapeutic landscape. Prospective studies integrating repeat tissue sampling, comprehensive genomic profiling, biomarker-guided patient stratification, pharmacogenomics, functional drug-sensitivity testing where feasible, and integrated multi-omics approaches are needed to advance molecularly guided and individualized treatment for T-SCLC.
Mingfeng Wei, Zheng Li, Kai Zhu et al.· Frontiers in Medicine· 0 citations
The motion controller is one of the most fundamental modules in embodied intelligence systems. Driven by large-scale human motion-capture data and the motion-tracking paradigm, humanoid control has achieved remarkable progress in recent years. However, migrating this recipe to the quadrupedal setting is far less straightforward: animal motion data is scarcer and harder to capture at scale than human data, and cross-embodiment retargeting remains fragile. We present ABot-C0, a generalist motion-control system for quadruped robots that establishes three complementary behavior foundations: a scalable multi-source motion-data pipeline, robust policy learning across motion tracking, locomotion, and scene interaction, and a unified deployment stack for reliable real-world operation. Fundamentally, we construct a data pyramid through conditional video-generation synthesis, annotated motion capture, teleoperation, and human design, producing 16,074 physically feasible motion clips as the data foundation for diverse motion-learning demands. With large-scale motion data, a Flow-Matching generalist policy demonstrates, for the first time, a scaling law for quadruped motion tracking: performance improves consistently as training scales up, with zero-shot capability to track unseen motions. We then go a step further toward robust all-terrain locomotion by adopting a three-stage privileged-to-perceptive framework with temporal LiDAR memory and terrain-predictive supervision. Collectively, these components form a motion generalist that coordinates multi-policy execution, smooth behavior transitions, energy-efficient control, and safety mechanisms for real-world deployment. Extensive experiments on urban-terrain autonomous navigation and companion-style multimodal interaction demonstrate that quadruped robots can move beyond functional demos toward product-level behavioral intelligence.
Xufeng Zhao, Fuzhi Yang, Jianhui Chen et al.· 0 citations
