Open access
Sep 2026
The gene-regulatory evolution of the human skeleton.
A coordinated evolutionary remodelling of the human skeletal ECM is revealed, including a marked suppression of glycosaminoglycan biosynthesis, leading to an approximately three-to-fourfold reduction in joint GAG content in humans compared with non-human apes.
Yi-Zhi Yan, Nadav Mishol, Katharina Lange et al.
· Nature · 1 citation