Author

Fumitaka Osakada

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Open access Aug 2026

AAV-DJ enables efficient, function-preserving neuronal transduction for circuit interrogation in human cortical and thalamic organoids.

A capsid-dependent trade-off between transduction efficiency and functional integrity is revealed and AAV-DJ is identified as an optimal serotype for robust gene delivery and physiological interrogation in organoid-based neuroscience.

Shota Adachi, Masatoshi Nishimura, Kosuke Yamaguchi et al. · Cell Reports Methods · 0 citations

Open access Jul 2026

A hypofunctional PREX1 variant (p.Y191C) leads to neurodevelopmental abnormalities and epilepsy by attenuating RAC1 signaling.

Results indicate that reduced PREX1-RAC1 signaling leads to mislocalization, dendritic overgrowth, and neuronal hyperexcitability, which may underlie epilepsy in the human case.

Masashi Nishikawa, Yuri Uchiyama, Kazuyuki Nakamura et al. · Scientific Reports · 0 citations