Author

Fusheng Zhou

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Open access Oct 2026

GFH312 Reduces Neuronal Death by Inhibiting RIPK1‐Mediated Apoptosis and Necroptosis After Ischemic Stroke

ABSTRACT Aims To investigate the role of the RIPK1 inhibitor GFH312 in ischemic stroke and identify its potential mechanisms. Methods GFH312 was administered to adult mice in an ischemic stroke model. To ascertain the effectiveness of treatment, neurobehavioral tests and assessments of brain damage were carried out. Br...

Ze Liu, Sheng-Ju Wu, Qian Suo et al. · CNS Neuroscience & Therapeut... · 0 citations

Open access Jul 2026

Development and Validation of a Sensitive UHPLC-MS/MS Analytical Method for Fulzerasib in Rat Plasma and its Application to Pharmacokinetics Studies.

The validated method was successfully applied in the first pharmacokinetic study of Fulzerasib in Sprague-Dawley rats following single intravenous and oral administration, and exhibited favorable pharmacokinetic properties, including low plasma clearance, moderate volume of distribution and notably high oral bioavailab...

Qiang Liu, Jin-Zhu Zhao, Li Wang et al. · Biomedical chromotography · 0 citations