Open access
Jul 2026
Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA
An electron cryomicroscopy structure of the 60 kDa CdrA adhesive N-terminus is reported, which combined with electron cryotomography of focused-ion beam milled specimens, allows for a complete in situ model of the native adhesin and reveals a small adhesive domain (called ADEPT) at the distal tip of CdrA that is nearly perfectly conserved across the P. aeruginosa pangenome.
Olivia E. R. Smith, Camila M. Clemente, Antonina Andreeva et al.
· bioRxiv · 0 citations