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Author

G. Aumont-Rodrigue

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Open access Sep 2026

Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology

Lysosomal dysfunction contributes to Alzheimer's disease (AD) by impairing protein clearance and promoting neuroinflammation. Cathepsin H (CTSH), a lysosomal protease, recently emerged as a protective AD locus. We investigated how CTSH is regulated and how it influences early AD pathophysiology.

C. Picard, G. Aumont-Rodrigue, I. Sarty et al. · 0 citations

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