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Open access Aug 2026

A two-year single-site longitudinal assessment of brain and retinal atrophy in ocrelizumab-treated relapsing–remitting multiple sclerosis

Ocrelizumab is an effective treatment for relapsing–remitting multiple sclerosis (RRMS), but its impact on brain and retinal atrophy requires further investigation. To assess the effects of ocrelizumab on brain and retinal atrophy over two years and explore the relationship between imaging biomarkers, early inflammat...

M. Cellerino, C. Lapucci, S. Magon et al. · 0 citations
Nov 2025

DTI‐ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi‐Modal MRI

1.1 Background The glymphatic system facilitates clearance of metabolic waste and pathological proteins from the brain, and its dysfunction has been implicated in neurodegenerative disease. The diffusion tensor imaging–analysis along the perivascular space (DTI-ALPS) has been proposed as a non-invasive MRI marker of gl...

L. Sacchi, Giovanni Farruggio, Giorgio Bocca et al. · 1 citation

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