G. Boland

Precision Oncology in Melanoma and Skin Cancer Surgery.

There has been perhaps no greater advance in the prognosis of solid tumors in the last decade than for patients with metastatic melanoma. This is due to significant improvements in treatment based on two key components of melanoma tumor biology (1) the identification of driver mutations with therapeutic potential and (...

A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity 2258066

The alpha-variant wave of the COVID-19 pandemic provided a unique opportunity to study, at single-cell resolution, how near-universal exposure to the same pathogen can lead to either effective or dysfunctional immune responses in humans. We analyzed 2.5 million circulating immune cells from 428 patients ac...

Hepatic CD8+TOX+ T-cells are a hallmark of autoimmune hepatitis