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Author

G. Brandão

h-index 21 View on Semantic Scholar

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Open access Sep 2026

Eugenol‐Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights

Findings identify D7 as a promising antiviral lead compound and provide a foundation for further mechanistic, optimization, and in vivo studies aimed at developing anti‐alphavirus therapeutics.

A. C. C. Reis, Amália Luíza de Sousa da Silva, Camila Portruneli et al. · 0 citations
Open access Aug 2026

Identification of 4-Amino-7-chloroquinoline Derivative with In Vitro Activity Against Chikungunya Virus

Among the tested compounds, derivative 6 demonstrated the most pronounced anti-CHIKV activity, with a low micromolar effective concentration and moderate selectivity index, and was identified as a potential lead candidate for further development against CHIKV.

A. C. C. Reis, Camila Portruneli, L. da Cunha Agostini et al. · 0 citations
Open access Jul 2026

Evaluation of the Antiviral Activity of Monomeric, Dimeric, and Oligomeric Flavonoids against Chikungunya and Mayaro Viruses

Results identify PC1 as the most promising candidate for future preclinical development, whereas GNT and PA2 should be considered lead compounds for further optimization strategies aimed at improving selectivity and safety profiles.

Delaine Meireles Gouvêa, Maria Cecília Muniz de Souza Brand, Millena Alves Máximo Vaz et al. · 0 citations

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