During mitotic growth,
Saccharomyces cerevisiae
cells age by dividing asymmetrically, producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and fully resets precursor cell lifespan, even for replicatively aged cells...
Silvan Spiri, T. Sing, Nhi Phung et al.· Nature Communications· 0 citations
This work identifies Gim3, a subunit of the ubiquitously expressed and conserved prefoldin complex, as a critical regulator of meiotic but not mitotic chromosome segregation in budding yeast and reveals an exciting and previously unrecognized link between chromosome segregation and meiotic cellular remodeling.
Naohiro Kuwayama, Benjamin S. Styler, Bojana Stekovic et al.· Science Advances· 0 citations
It is found that the endogenous UPR that precedes meiosis in budding yeast is required for gamete production but diverges dramatically from previously defined UPR outputs, with only a few characterized UPR targets induced, and mildly.
Constantine Bartolutti, Alena L. Bishop, Yanzhe Ma et al.· Journal of Cell Biology· 0 citations
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