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Review Open access Sep 2026

Breaking the proteasome balance: α-synuclein and the ubiquitin-proteasome system

Aging is the major risk factor for synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. However, the molecular mechanisms linking aging to. α-Synuclein cytotoxicity remain incompletely understood. The progressive decline of proteostasis is central among these mechani...

Tariq T. Ali, B. Popova, G. Braus · 0 citations
Open access Jul 2026

Functional dissection of velvet DNA-binding region in Aspergillus nidulans VelB uncovers an essential conserved arginine cluster

It is established that a cluster of conserved arginine residues generates the positive electrostatic surface potential required for velvet–DNA interaction and define the molecular basis of DNA recognition by this ancient family of fungal transcription factors.

Wanping Chen, Anna M. Köhler, Ming-Rong Deng et al. · 0 citations

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