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Author

George M. Burslem

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Aug 2026

General Strategy for Controlling Functional Lysine Acetylation via Induced Proximity.

Assigning causal function to post-translational modifications (PTMs) remains a central challenge in molecular biology, as most modification events cannot be readily interrogated in their native cellular context. Here, we present a generalizable chemical biology strategy for investigating the functional consequences of...

Brianna Hill-Payne, Mohd Younis Bhat, G. Burslem · 0 citations
Open access Aug 2026

Repositioning of polyubiquitin alters the pathologic tau filament structure.

It is found that polyubiquitinated tau filaments from Alzheimer disease and vacuolar tauopathy human brain tissue exhibit distinct seeding patterns in mice, in association with differences in tau filament ultrastructure determined by cryo-electron microscopy.

Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich et al. · 1 citation

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