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G. Caliendo

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Review Open access Oct 2026

Hereditary cancer syndromes as a model for precision oncology: the paradigms of HRD and MSI.

Hereditary cancer syndromes such as BRCA-associated and Lynch syndrome have provided a clinical framework for understanding the molecular underpinnings of homologous recombination deficiency (HRD) and microsatellite instability (MSI). These phenotypes have reshaped precision oncology by enabling biomarker-driven use of...

C. Della Pepa, A. Mignano, Marialaura Zitiello et al. · 0 citations

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