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Review Open access Sep 2026

P2X7 Receptor in Rare Diseases: Shared Molecular Mechanisms and Therapeutic Implications

Abstract Rare diseases (RDs) are individually uncommon but collectively affect a large global population, and the vast majority still lack effective disease-modifying therapies. With advances in genomics and data-sharing platforms, research has increasingly shifted from a single-disease perspective to the search for co...

Xin-Yi Xiao, G. Cao, Shuai Hou et al. · 0 citations
Open access Sep 2026

ECC-MR: an error-correcting-code framework for robust Mendelian randomization and pleiotropy decoding on correlated instruments

Mendelian randomization (MR) uses genetic variants as instrumental variables for causal inference, but its validity is often undermined by horizontal pleiotropy and linkage disequilibrium (LD) among instruments, which current methods typically address by discarding correlated or outlying variants. Here we present ECC-M...

J. Jiang, D. Hu, Q. Zhang et al. · 0 citations

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