Author

G. Castaman

2 papers indexed here

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Review Open access Oct 2026

Von Willebrand Disease (VWD) 100 years after its first description: the research of Italian investigators for a better management of VWD patients

Since the first description of the von Willebrand disease (VWD) families by Erik von Willebrand in 1926, VWD has been considered an inherited bleeding disorder completely different from hemophilia, already known for many years. The pivotal role of the adhesive glycoprotein von Willebrand factor in the early phases of h...

A. B. Federici, G. Castaman, Paolo Gresele et al. · Bleeding Thrombosis and Vasc... · 0 citations

Open access Aug 2026

Factor IX gene variants may influence the pharmacokinetic profile of patients with hemophilia B treated with FIX-Fc or N9-GP extended half-life FIX concentrates.

BACKGROUND FIX exhibits significant extravascular distribution and binds type IV collagen in the subendothelial extracellular matrix in the extravascular space, which influences its function and pharmacokinetics (PK). Many hemophilia B patients carry missense F9 mutations that produce circulating, dysfunctional FIX pro...

D. Matino, Z. Al-Housni, B. Samelson-Jones et al. · Journal of Thrombosis and Ha... · 0 citations