Review
Open access
Sep 2026
A bittersweet symphony: soluble mediator networks orchestrate melanoma plasticity and therapeutic adaptation
It is proposed that soluble mediator networks, including cytokines, chemokines, growth factors, metabolites, extracellular vesicle-associated signals, and stress-related mediators, provide a functional layer that links the different compartments of the melanoma TME.
Carmine Lauretta, Carmela Sorrentino, Emilia Sabbatino et al.
· Frontiers in Cell and Develo... · 0 citations