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Author

G. Dekkers

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Open access Sep 2026

Identification of a C3b-specific nanobody that does not bind C3 and blocks alternative pathway convertases

C3b-specific nanobodies are developed by generating phage libraries from llamas immunized with purified and surface-bound C3b and Functionally, UNbC3b-1 inhibits complement activity in the alternative pathway (AP), likely by preventing association between substrate C3 and the AP C3 convertase (C3bBb).

Eva M. Struijf, B. Bardoel, Joanne E. van Keulen et al. · 0 citations
Open access Sep 2026

Siglec-1-targeting single domain antibodies block or enhance pathogen binding to dendritic cells

High-affinity single domain antibodies, (also known as VHHs or Nanobodies) that allo- or orthosterically modulate ligand binding of Siglec-1 are identified and may serve as broad-spectrum pathogen blocking agents.

H. J. Brink, A. Affandi, S. Man et al. · 0 citations
Open access Jul 2026

Anti-capsid nanobodies function as HIV-1 capsid inhibitors by intracellular capsid degradation

A capsid-targeting biological composed of a single-domain Llama VHH that binds CA, fused to human IgG1 Fc to activate TRIM21-mediated degradation results in inhibition of viral replication through TRIM21-mediated proteasome degradation of the HIV-1 capsid, establishing capsid-directed biologicals as therapeutic strateg...

Floor M. Stel, Charlotte E. J. Verkuijlen, Esther M. Zijlstra-Willems et al. · 1 citation

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