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Author

G. Dell’Isola

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Review Open access Oct 2026

Beyond seizures: the hidden burden of developmental epileptic encephalopathies

Developmental and epileptic encephalopathies (DEEs) are a group of severe childhood-onset disorders characterized by drug-resistant epilepsy and a broad spectrum of neurodevelopmental, behavioral, psychiatric, and systemic manifestations. Although seizure control has traditionally been the primary therapeutic goal, gro...

G. Dell'Isola, Michele Sorrentino, Sara Massara et al. · 0 citations
Review Aug 2026

New and emerging pharmacotherapeutic options for the treatment of pediatric focal epilepsies.

Current and emerging pharmacotherapeutic options for selected representative pediatric focal epilepsies are summarized using a syndrome- and localization-oriented approach, highlighting conventional antiseizure medications, newer agents, and investigational or repurposed treatments.

L. Perilli, G. Dell’Isola, Pietro Ferrara et al. · 0 citations
Open access Jul 2026

Expanding clinical variability in FBXW7-related neurodevelopmental disorder: a multicenter case series

A retrospective multicenter case series of seven previously unreported individuals with heterozygous FBXW7 variants identified through clinical genetic testing expands the phenotypic spectrum associated with FBXW7-related neurodevelopmental disorder and highlights variable expressivity and incomplete penetrance.

Salvatore Savasta, F. Comisi, G. Dell’Isola et al. · 0 citations

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