G. DeLuca

Multimodal discovery of a pathogenic B cell-dependent T cell state in multiple sclerosis.

B cell depleting therapies in multiple sclerosis (MS) have transformed disease management, yet the immunological mechanisms linking B cells to chronic compartmentalised CNS inflammation, the key pathological driver of disability accrual, remain poorly defined. Here, we leverage anti-CD20 therapy as an in vivo perturbat...