Author

G. Diss

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Open access Sep 2026

A designed ubiquitin-binding protein selectively enriches and visualizes unanchored ubiquitin

While protein ubiquitination has been extensively studied, the roles of unanchored ubiquitin and its chains remain less understood, largely due to a lack of specific, high-affinity tools for their enrichment and visualization. To address this, we used high-throughput affinity maturation and computational protein design...

Shi-Hua Shi, A. Bendel, G. Kempf et al. · Science Advances · 0 citations

Open access Aug 2026

Proteome-wide identification of the druggable CRBN interactome.

Molecular glue degraders (MGDs), such as pomalidomide, induce degradation of non-native substrates by the cullin-RING E3 ligase 4 (CRL4) through its substrate receptor cereblon (CRBN). Here, to explore CRBN programmability, we tested whether reported CRBN-MGD substrates are part of a network of latent CRBN interactors,...

Pius Galli, Shuhao Xiao, Y. Meng et al. · Nature Biotechnology · 0 citations