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Author

G. Dobreva

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Open access Jul 2026

Reassessing Tcf21-iCre for Adult Cardiac Fibroblast Gene Deletion: Limited Recombination Efficiency Following Tamoxifen Injections

Tcf21-iCre cannot reliably achieve broad gene deletion in adult cardiac fibroblasts with i.p. tamoxifen injection, limiting its usability in loss-of-function studies that require broad fibroblast coverage and highlighting the need for alternative Cre-drivers or delivery strategies to facilitate antifibrotic therapy dev...

A. Schober, Lukas Müller, R. Wardman et al. · 0 citations
Review Jul 2026

The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing.

The nucleus is a highly organized and dynamic organelle, with hierarchical layers ranging from nucleosome positioning to chromatin domains and higher-order 3D genome topology, and this organization enables precise and context-dependent transcriptional control.

Yi-Nuo Wang, G. Dobreva · 1 citation

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