G. Doss C

Computationally guided discovery of novel inhibitors targeting Acinetobacter-derived cephalosporinase (AmpC) through structure-based methodologies.

Acinetobacter baumannii is a critical opportunistic pathogen responsible for a global health crisis, driven primarily by the rising prevalence of multidrug-resistant (MDR) strains. A central mechanism of β-lactam resistance in A. baumannii involves the overexpression of the class C β-lactamase AmpC, which degrades a wi...

Genomic and structural insights into the atpB L173I substitution: modulation of the F₀ rotor architecture in Mycobacterium tuberculosis ATP synthase and altered Bedaquiline binding dynamics