G. E. Atilla-Gokcumen

Modulation Sterol Regulatory Element-Binding Protein Signaling: Mechanisms, Probes, and Roles in Disease.

Maintenance of lipid homeostasis requires cells to coordinate lipid synthesis precisely. Sterol regulatory element-binding proteins (SREBPs) represent one of the central mechanisms by which cells sense lipid availability and adjust the biosynthesis of fatty acids, cholesterol, and phospholipids in response to metabolic...

Beyond Total PFAS: Isomer Composition Matters for Water Quality and Human Exposure Studies.

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

It is reported that loss of the lactate receptor GPR81 in cellular and progeroid models of muscle aging is associated with impaired lipid oxidation and enhanced lipid accumulation, and agonists of GPR81 might play a promising role in reversing age‐associated lipid accumulation and loss of muscle function.