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Author

G. Filomeni

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Open access Aug 2026

Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers

It is demonstrated that pharmacological inhibition of the glyoxalase system—the major pathway for MGO detoxification—restores drug sensitivity in patient-derived cells and xenograft models, revealing a context-dependent metabolic vulnerability in AKR1A1 loss conditions.

Chiara Pecorari, Mojca Bratina, Evelyn Gonzalez et al. · 1 citation

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