OBJECTIVE
Abnormalities in posteriorly dominant resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are associated with cerebrospinal fluid (CSF) tau neuropathology and Mini-Mental Status Examination (MMSE) score, reflecting global cognition, in patients with mild cognitive impairment due to Alzheim...
C. Del Percio, R. Lizio, G. Noce et al.· Clinical Neurophysiology· 0 citations
Although radiological severity thresholds for amyloid-related imaging abnormalities with hemosiderin deposition (ARIA-H) were developed using 2-dimensional acquisitions of T2*-weighted gradient-recalled echo (T2*GRE) MRI in pivotal anti-amyloid trials, adoption of well established 3D susceptibility-weighted imaging (SW...
Meike W. Vernooij, T. G. Oliveira, Roland Wiest et al.· Neuroradiology· 0 citations
The recent approval of disease-modifying therapies for symptomatic Alzheimer's disease is a major advance for a condition with few therapeutic options. Anti-amyloid monoclonal antibodies have shown clinically meaningful benefits in slowing cognitive decline. Clinical trials in symptomatic Alzheimer's disease suggest th...
J. Graff-Radford, Leah Karliner, Deborah E. Barnes et al.· Lancet Neurology· 1 citation
Findings support a 3-level interpretation of amyloid PET beyond binary classification and highlight the clinical relevance of the intermediate zone, which delineates biologically and clinically distinct stages along the amyloid continuum.
G. Mathoux, C. Boccalini, D. Peretti et al.· Journal of Nuclear Medicine· 0 citations
The Amyloid Imaging to Prevent Alzheimer’s Disease Prognostic and Natural History Study (AMYPAD-PNHS) multimodal magnetic resonance imaging (MRI) dataset provides open-access longitudinal MRI data of 2759 cognitively normal or mild cognitive impairment individuals to enhance generalizability and comparability between f...
L. Pieperhoff, M. Tranfa, Prithvi Arunachalam et al.· Scientific Data· 0 citations
Generalized additive models examined clinical progression on the basis of visual and CenTauRz-based assessments of tau PET positivity and highlighted the need for new quantification approaches to better capture the complex patterns of tau deposition, important for early AD detection and monitoring.
Stamatia Karagianni, Alexis Moscoso, Sheelakumari Raghavan et al.· Journal of Nuclear Medicine· 0 citations
Ratios combining biomarkers of both amyloid and tau, such as Aβ42/pTau, consistently outperformed individual biomarkers in detecting amyloid and tau PET positivity and enhanced clinical utility by highlighting ambiguous cases requiring further assessment.
Sophie Mutel, F. Ribaldi, Augusto J. Mendes et al.· Alzheimer's Research & T...· 0 citations
A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).
G. Blazhenets, D. Soleimani-Meigooni, Konstantinos Chiotis et al.· Journal of the American Medi...· 5 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
