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G. Giardina

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Open access Sep 2026

Cell-cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors

The relationship between cell cycle length and differentiation competence has been studied in developmental biology, particularly in embryonic stem cells, which show a very short G1 phase required to maintain pluripotency. How and whether this principle operates in cancer— where the cell cycle is deregulated and G1 is...

K. Hayatigolkhatmi, R. Valzelli, E. Ceccacci et al. · 0 citations
Open access Aug 2026

Nanoparticles-mediated dual drug administration boosts therapeutic efficacy in drug resistant melanoma.

A dual-drug delivery system co-loading trametinib, MEK inhibitor, and alisertib, Aurora A kinase inhibitor was developed, optimized to maintain a previously established synergistic ratio which effectively overcome acquired resistance to standard-of-care therapies and induce durable tumor regression.

Giulia Lovati, Pietro Milesi, Paolo Fossati et al. · 0 citations

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