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G. Jeong

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Review Open access Aug 2026

Mitochondrial Dysfunction as a Driver of Meta-Inflammation in Aging: The Emerging Role of PDK4 in Bioenergetic Reprogramming and Inflammatory Amplification

The PDK4–PDH axis provides a useful framework for understanding how mitochondrial fuel restriction may contribute to chronic inflammation across aging tissues, including skeletal muscle, adipose tissue, brain, and kidney, and therapeutic strategies aimed at restoring mitochondrial function to suppress chronic inflammation and preserve healthspan are evaluated.

Md Riad Chowdhury, G. Jeong, In-Kyu Lee · 0 citations