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Open access Sep 2026

Safety and antitumor activity of the first-in-class EGFR-HER3 bispecific antibody-drug conjugate iza-bren (BL-B01D1) in patients with pretreated locally advanced or metastatic breast cancer: a phase 1b study.

BACKGROUND Bispecific antibody-drug conjugates (ADCs) may overcome limitations of monospecific ADCs. We report results from a phase 1b study of iza-bren, a first-in-class EGFR-HER3 bispecific ADC, in patients with heavily pretreated locally advanced or metastatic breast cancer. PATIENTS AND METHODS This multicenter s...

J. Zhang, Y. Meng, Y. Du et al. · 0 citations
Open access Jul 2026

Internal validation of a residual thyroid recurrence model after PTC

An innovative clinical prediction model specifically designed to assess the risk of recurrence in residual thyroid tissue is developed and validated and serves as a valuable tool for clinicians, facilitating personalized decision-making and representing a significant advancement in the postoperative management of papil...

Ruohan Shi, Lisen Zhu, Jia Liu et al. · 0 citations

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