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Author

G. Karakülah

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2 papers indexed here

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Open access Oct 2026

KATNAL2 dysfunction impairs microtubule dynamics and contributes to syndromic neurodevelopmental disease

Abstract Katanins are microtubule-severing ATPases. Dysfunction of katanin subunits has been implicated in impaired neurogenesis, morphogenesis, and neuronal migration. Although heterozygous variants in KATNAL2 (katanin-like 2), a known autism-spectrum disorder (ASD) risk gene, have been reported in patients with ASD o...

Ece Sonmezler, Semra Hız Kurul, Ozlem Erez et al. · 0 citations
Open access Sep 2026

Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles

Organoids are self‐organized, in vitro 3D structures derived from progenitor or pluripotent stem cells. During culture, these tissues secrete small extracellular vesicles (sEVs)—functional bioactive molecules—into their microenvironment. Here, we differentiated iPSC‐derived cerebral organoids (COs) under three culture...

Elifsu Polatlı, Burak Kahveci, C. Kiser et al. · 0 citations

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