Open access
Aug 2026
A synthetic biology approach to bacterial transcription initiation: RNA aptamer based in vitro transcription assay for rapidly testing bacterial RNA polymerases, promoters and inhibitors
The Broccoli-based IVT system is established as a highly adaptable platform for quantifying promoter strength and screening small-molecule inhibitors of bacterial transcription and its utility for drug discovery is demonstrated.
Tina Lanzmaier, Elena Reiterer, Melanie Merl et al.
· bioRxiv · 0 citations