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Open access Sep 2026

Uncoupling of the allosteric signalling network in the β1-adrenergic receptor by a negative allosteric modulator

Allosteric modulation is a fundamental aspect of G protein-coupled receptor (GPCR) regulation where molecules that bind to alternative sites outside the orthosteric pocket alter agonist-induced signalling responses. The advantages of allosteric modulators over traditional orthosteric agonists have positioned them a...

Thomas H. Harman, Timothy Noel, Ali Nokhbehzaim et al. · 0 citations
Open access Aug 2026

Molecular arrangement and modulation of extrasynaptic αβδ GABAA receptors

Key insights are provided into the stoichiometry, arrangement and molecular modes of GABA activation and δ-selective modulation of these critical regulators of neuronal excitability of GABAA αβδ receptors.

Stephanie A. Nestorow, Wan-Na Chen, D. Bertrand et al. · 0 citations

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