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Open access Aug 2026

Enhancing TGF-β1 production in CHO cells via MS-275 treatment, Bax/Bak knockout, and PACEsol overexpression

Efficient production of recombinant human transforming growth factor-β1 (rhTGF-β1) in Chinese hamster ovary (CHO) cells is limited by low yields and inefficient precursor processing. Here, we developed an integrated strategy combining chemical and genetic engineering. Screening of additives revealed that the histon...

Kyungsoo Kim, Kyoung Eun Baek, G. Lee · 0 citations

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