Aug 2026
In vivo evaluation of the dual MOP/NOP agonist AT121: a potent analgesic that delays opioid tolerance and offers a superior withdrawal suppression profile to methadone.
To evaluate the in vivo analgesic efficacy, tolerance liability, and dependence-modulating potential of AT121, a dual μ-opioid (MOP)/nociceptin (NOP) partial agonist, compared with morphine in Wistar rats. Male Wistar rats (n = 264) underwent tail-flick thermal nociception assays to assess dose-response and duration of...
Baraa E Elawy, Loai Aljerf, Shaza A Allaham et al.
· Neuroscience · 0 citations