BACKGROUND
Individuals with Parkinson's disease (PD) carrying GBA1 variants often develop advanced motor complications that prompt evaluation for deep brain stimulation (DBS). However, concerns about accelerated cognitive decline after DBS in GBA1 carriers complicate clinical decision making. A critical aspect that is...
E. Asimakidou, M. Avenali, J. Aasly et al.· Movement Disorders· 0 citations
Parkinson’s disease is a neurodegenerative disorder characterized by altered subcortical-cortical connectivity, leading to motor and cognitive deficits. Saccadic eye movement abnormalities are among the earliest and most persistent markers of the disease, serving as sensitive indicators of disrupted oculomotor and cogn...
Varsha Vasudevan, Sandy Mournet, B. Béranger et al.· bioRxiv· 0 citations
It is demonstrated that phenoconversion in iRBD relates similarly to dopaminergic denervation of the putamen and cell loss in the SN, which opens possibilities for using NM-MRI, which can simultaneously capture dopaminergic and noradrenergic deficits, as an alternative to nuclear imaging techniques when estimating phen...
M. Johansson, A. Baron, R. Gaurav et al.· medRxiv· 0 citations
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